Endocrine Abstracts

Background: 5-hydroxyindole acetic acid (5-HIAA), a metabolite of serotonin, is used as a marker for patients with serotonin-secreting neuroendocrine tumours (NET). Currently, the majority of laboratories measure 5-HIAA excretion in 24 h urine samples. Given the practicality and analytic problems of these samples, our laboratory successfully developed a LC–MS/MS method for the analysis of 5-HIAA in serum samples. Further to this, we have now developed a method to measure ...